Fast, Constraint-Based Threading of HP-Sequences to Hydrophobic Cores
Identifieur interne : 002688 ( Main/Exploration ); précédent : 002687; suivant : 002689Fast, Constraint-Based Threading of HP-Sequences to Hydrophobic Cores
Auteurs : Rolf Backofen [Allemagne] ; Sebastian Will [Allemagne]Source :
- Lecture Notes in Computer Science [ 0302-9743 ] ; 2001.
Abstract
Abstract: Lattice protein models are used for hierarchical approaches to protein structure prediction, as well as for investigating principles of protein folding. So far, one has the problem that there exists no lattice that can model real protein conformations with good quality and for which an efficient method to find native conformations is known. We present the first method for the FCC-HP-Model [3] that is capable of finding native conformations for real-sized HP-sequences. It has been shown [23] that the FCC lattice can model real protein conformations with coordinate root mean square deviation below 2 Å. Our method uses a constraint-based approach. It works by first calculating maximally compact sets of points (hydrophobic cores), and then threading the given HP-sequence to the hydrophobic cores such that the core is occupied by H-monomers.
Url:
DOI: 10.1007/3-540-45578-7_34
Affiliations:
Links toward previous steps (curation, corpus...)
- to stream Istex, to step Corpus: 001364
- to stream Istex, to step Curation: 001045
- to stream Istex, to step Checkpoint: 001F25
- to stream Main, to step Merge: 002741
- to stream Main, to step Curation: 002688
Le document en format XML
<record><TEI wicri:istexFullTextTei="biblStruct"><teiHeader><fileDesc><titleStmt><title xml:lang="en">Fast, Constraint-Based Threading of HP-Sequences to Hydrophobic Cores</title>
<author><name sortKey="Backofen, Rolf" sort="Backofen, Rolf" uniqKey="Backofen R" first="Rolf" last="Backofen">Rolf Backofen</name>
</author>
<author><name sortKey="Will, Sebastian" sort="Will, Sebastian" uniqKey="Will S" first="Sebastian" last="Will">Sebastian Will</name>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">ISTEX</idno>
<idno type="RBID">ISTEX:F3BD849A332FDCDC7A67CC13F08E894B697D1326</idno>
<date when="2001" year="2001">2001</date>
<idno type="doi">10.1007/3-540-45578-7_34</idno>
<idno type="url">https://api.istex.fr/document/F3BD849A332FDCDC7A67CC13F08E894B697D1326/fulltext/pdf</idno>
<idno type="wicri:Area/Istex/Corpus">001364</idno>
<idno type="wicri:Area/Istex/Curation">001045</idno>
<idno type="wicri:Area/Istex/Checkpoint">001F25</idno>
<idno type="wicri:doubleKey">0302-9743:2001:Backofen R:fast:constraint:based</idno>
<idno type="wicri:Area/Main/Merge">002741</idno>
<idno type="wicri:Area/Main/Curation">002688</idno>
<idno type="wicri:Area/Main/Exploration">002688</idno>
</publicationStmt>
<sourceDesc><biblStruct><analytic><title level="a" type="main" xml:lang="en">Fast, Constraint-Based Threading of HP-Sequences to Hydrophobic Cores</title>
<author><name sortKey="Backofen, Rolf" sort="Backofen, Rolf" uniqKey="Backofen R" first="Rolf" last="Backofen">Rolf Backofen</name>
<affiliation wicri:level="3"><country>Allemagne</country>
<placeName><settlement type="city">Munich</settlement>
<region type="land" nuts="1">Bavière</region>
<region type="district" nuts="2">District de Haute-Bavière</region>
</placeName>
<wicri:orgArea>Institut für Informatik, LMU München, Oettingenstra\e 67, D-80538</wicri:orgArea>
</affiliation>
<affiliation wicri:level="1"><country wicri:rule="url">Allemagne</country>
</affiliation>
</author>
<author><name sortKey="Will, Sebastian" sort="Will, Sebastian" uniqKey="Will S" first="Sebastian" last="Will">Sebastian Will</name>
<affiliation wicri:level="3"><country>Allemagne</country>
<placeName><settlement type="city">Munich</settlement>
<region type="land" nuts="1">Bavière</region>
<region type="district" nuts="2">District de Haute-Bavière</region>
</placeName>
<wicri:orgArea>Institut für Informatik, LMU München, Oettingenstra\e 67, D-80538</wicri:orgArea>
</affiliation>
<affiliation wicri:level="1"><country wicri:rule="url">Allemagne</country>
</affiliation>
</author>
</analytic>
<monogr></monogr>
<series><title level="s">Lecture Notes in Computer Science</title>
<imprint><date>2001</date>
</imprint>
<idno type="ISSN">0302-9743</idno>
</series>
<idno type="istex">F3BD849A332FDCDC7A67CC13F08E894B697D1326</idno>
<idno type="DOI">10.1007/3-540-45578-7_34</idno>
<idno type="ChapterID">Chap34</idno>
<idno type="ChapterID">34</idno>
</biblStruct>
</sourceDesc>
</fileDesc>
<profileDesc><textClass></textClass>
<langUsage><language ident="en">en</language>
</langUsage>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en">Abstract: Lattice protein models are used for hierarchical approaches to protein structure prediction, as well as for investigating principles of protein folding. So far, one has the problem that there exists no lattice that can model real protein conformations with good quality and for which an efficient method to find native conformations is known. We present the first method for the FCC-HP-Model [3] that is capable of finding native conformations for real-sized HP-sequences. It has been shown [23] that the FCC lattice can model real protein conformations with coordinate root mean square deviation below 2 Å. Our method uses a constraint-based approach. It works by first calculating maximally compact sets of points (hydrophobic cores), and then threading the given HP-sequence to the hydrophobic cores such that the core is occupied by H-monomers.</div>
</front>
</TEI>
<affiliations><list><country><li>Allemagne</li>
</country>
<region><li>Bavière</li>
<li>District de Haute-Bavière</li>
</region>
<settlement><li>Munich</li>
</settlement>
</list>
<tree><country name="Allemagne"><region name="Bavière"><name sortKey="Backofen, Rolf" sort="Backofen, Rolf" uniqKey="Backofen R" first="Rolf" last="Backofen">Rolf Backofen</name>
</region>
<name sortKey="Backofen, Rolf" sort="Backofen, Rolf" uniqKey="Backofen R" first="Rolf" last="Backofen">Rolf Backofen</name>
<name sortKey="Will, Sebastian" sort="Will, Sebastian" uniqKey="Will S" first="Sebastian" last="Will">Sebastian Will</name>
<name sortKey="Will, Sebastian" sort="Will, Sebastian" uniqKey="Will S" first="Sebastian" last="Will">Sebastian Will</name>
</country>
</tree>
</affiliations>
</record>
Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Musique/explor/MozartV1/Data/Main/Exploration
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 002688 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd -nk 002688 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien |wiki= Wicri/Musique |area= MozartV1 |flux= Main |étape= Exploration |type= RBID |clé= ISTEX:F3BD849A332FDCDC7A67CC13F08E894B697D1326 |texte= Fast, Constraint-Based Threading of HP-Sequences to Hydrophobic Cores }}
This area was generated with Dilib version V0.6.20. |